425 GRPR is an effective target for melanoma

Autophagy- An emerging target for melanoma therapy

Melanoma accounts for only 5% of all cancers but is the leading cause of skin cancer death due to its high metastatic potential. Patients with metastatic melanoma have a 10-year survival rate of less than 10%. While the clinical landscape for melanoma is evolving rapidly, lack of response to therapies, as well as resistance to therapy remain critical obstacles for treatment of this disease. In ...

IQGAP1 is an oncogenic target in canine melanoma

Canine oral mucosal melanoma is an aggressive malignant neoplasm and is characterized by local infiltration and a high metastatic potential. The disease progression is similar to that of human oral melanomas. Whereas human cutaneous melanoma is primarily driven by activating mutations in Braf (60%) or Nras (20%), human mucosal melanoma harbors these mutations much less frequently. This makes th...

Vitamin D Food Fortification is an Effective Approach for Improving Vitamin D Status; A Systematic Review

Background: Low vitamin D (vit D) serum levels have been linked to various diseases such as multiple sclerosis, cardiovascular diseases, and diabetes. Maintenance of optimal vit D level should be supported by foods and supplements. Limited food sources of vit D made researchers focus on food fortification in recent years. Methods: A systematic review of randomized controlled trials reporting th...

Clinical inquiries. Is training patients in self-examination an effective way to screen for melanoma?

Topical Diphencyprone as an Effective Treatment for Cutaneous Metastatic Melanoma

Vol. 24, No. 3, 2012 373 Received September 9, 2011, Revised September 29, 2011, Accepted for publication September 29, 2011 Corresponding author: Young Jin Kim, M.B., B.S., Department of Dermatology, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba Queensland 4102, Australia. Tel: 61-425-247-302, Fax: 61-73176-7344, Email: [email protected] This is an Open Access article distr...